Tyrosine kinase inhibitors: relapse prophylaxis after allogeneic hematopoietic stem cell transplantation in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia
نویسندگان
چکیده
Ингибиторы тирозинкиназ: профилактика рецидива после аллогенной трансплантации гемопоэтических стволовых клеток у взрослых пациентов с Ph-позитивным острым лимфобластным лейкозомTyrosine kinase inhibitors: relapse prophylaxis after allogeneic hematopoietic stem cell transplantation in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia
منابع مشابه
Isolated skin relapse of Philadelphia chromosome-positive acute lymphoblastic leukemia after allogeneic stem cell transplant
Leukemia cutis is a rare entity diagnosed in only 1–3% of Tand B-cell acute lymphoblastic leukemia (ALL).1,2 Aleukemic leukemia cutis (ALC) is an even rarer diagnosis, occurring without leukemic cells in the blood or marrow, often preceding systemic disease.2,3 The Philadelphia chromosome (Ph) is one of the most common chromosomal abnormalities in adult B-ALL patients and is associated with poo...
متن کاملProphylaxis and treatment of acute lymphoblastic leukemia relapse after allogeneic hematopoietic stem cell transplantation
Relapse of acute lymphoblastic leukemia remains a major cause of death in patients following allogeneic hematopoietic stem cell transplantation. Several factors may affect the concurrence and outcome of relapse, which include graft-versus-host disease, minimal residual disease or intrinsic factors of the disease, and transplantation characteristics. The mainstay of relapse prevention and treatm...
متن کاملTyrosine Kinase Inhibitor for Treatment of Adult Allogeneic Hematopoietic Stem Cell Transplantation Candidate with Philadelphia-Positive Acute Lymphoblastic Leukemia
Philadelphia‐positive acute lymphoblastic leukemia (Ph+ ALL) accounts for approximately 25–33% of all adult ALL cases. Its prognosis was dismal until the introduction of tyrosine kinase inhibitors (TKIs) in clinical applications. TKIs combined with chemotherapy resulted in higher rates of complete remission (CR) and complete molecular remission (CMR) compared with chemotherapy alone. However, a...
متن کاملTyrosine kinase inhibitors improve long-term outcome of allogeneic hematopoietic stem cell transplantation for adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia.
This study aimed to determine the impact of tyrosine kinase inhibitors given pre- and post-allogeneic stem cell transplantation on long-term outcome of patients allografted for Philadelphia chromosome-positive acute lymphoblastic leukemia. This retrospective analysis from the EBMT Acute Leukemia Working Party included 473 de novo Philadelphia chromosome-positive acute lymphoblastic leukemia pat...
متن کاملPhiladelphia chromosome-positive acute lymphoblastic leukemia with extramedullary and meningeal relapse after allogeneic hematopoietic stem cell transplantation that was successfully treated with dasatinib
Central nervous system (CNS) relapse is a critical issue while treating Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-positive ALL). A 58-year-old woman with Ph-positive ALL who relapsed after bone marrow transplantation for meningeal leukemia was treated with high-dose methotrexate, which resulted in remission. She underwent allogeneic cord blood transplantation followed by...
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ژورنال
عنوان ژورنال: Cellular therapy and transplantation
سال: 2022
ISSN: ['1867-416X', '1866-8836']
DOI: https://doi.org/10.18620/ctt-1866-8836-2022-11-3-4-45-59